By Edouard Kurstak (Auth.)
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Neutralizing antibody levels which would be expected to protect were also obtained when the peptide was inoculated into cattle. A challenge protection test in cattle is now underway. The potential of synthetic peptide FMD vaccines is enormous: (1) Pep- 27 2. Genetic Engineering in Animal Vaccine Production tides of different serotype specificity might be coupled to provide a balanced polyvalent vaccine. (2) Polymers of the peptides might be constructed to increase the number of antigenic determinants per molecule as a means of increasing potency (although folding of longer peptides limits epitope exposure).
Glutinin (HA) of influenza virus (Wilson et aL, 1981), the G protein of rabies (Cox et aL, 1977), the hemagglutinin-neuraminidase (HN) of paramyxoviruses (Choppin et aL, 1981), the glycoprotein of tick-borne encephalitis virus (Heinz et aL, 1983), and one of the glycoproteins in alphaviruses (Kääriäinen and Söderlund, 1978). Corresponding proteins have also been identified in DNA viruses, such as the surface antigen of hepatitis Β (HBsAg) (Szmuness et aL, 1981), or one or several of the membrane proteins of herpes simplex virus (HSV) (Lee et aL, 1982; Seigneurin et aL, 1983).
Grubman, M. , McKercher, P. , Morgan, D. , Robertson, Β. , and Bachrach, H. L. (1981). ) 214, 1125-1129. , Zaslavsky, V. , and Hofschneider, P. H. (1981). Nature (London) 289, 555-559. Lerner, R. A. (1983). Sei. Am. 248, 66-74. Murphy, F. A. (1983a). In "Viral Diseases in South-East Asia and the Western Pacific" (J. S. ). Academic Press, New York. Murphy, F. A. (1983b). In "Control of Virus Diseases" (E. Kurstak and R. G. ). Dekker, New York. Pond, W. , Merkel, R. , McGilliard, L. , and Rhodes, V.
Applied Virology by Edouard Kurstak (Auth.)