Download e-book for iPad: Aging and the Gastrointestinal Tract by A. Pilotto, P. Malfertheiner, P.R. Holt, T. Fulop

By A. Pilotto, P. Malfertheiner, P.R. Holt, T. Fulop

ISBN-10: 058547334X

ISBN-13: 9780585473345

ISBN-10: 3805575556

ISBN-13: 9783805575553

With the dramatic raise of the getting older inhabitants, the research and care of gastrointestinal problems within the aged became precedence themes for either clinicians and researchers. The geriatric procedure such as the epidemiology and pharmacokinetics of gear in addition to a accomplished multidimensional evaluation is very vital in dealing with older sufferers with gastrointestinal issues, given that those sufferers are inclined to have a number of interacting difficulties that intervene with their day-by-day functionality and complicate their therapy. This booklet offers the result of contemporary reports in geriatric gastroenterology and studies either easy and scientific features of the sphere. a big part is dedicated to the shut exam of the structural and sensible results of getting older at the body structure of the gastrointestinal tract.

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Pharmacokinetic and clinical considerations. Drugs Aging 1997;10:259–277. Fliser D, Franek E, Joest M, Block S, Mutschler E, Ritz E: Renal function in the elderly: Impact of hypertension and cardiac function. Kidney Int 1997;51:1196–1204. Fliser D, Bischoff I, Hanses A, Block S, Joest M, Ritz E, Mutschler E: Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged. Eur J Clin Pharmacol 1999;55:205–211. Aging and Drug Disposition 37 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Zhang Y, Benet LZ: The gut as a barrier to drug absorption.

References 1 2 3 4 5 6 7 8 9 10 Winkler MA: Aging: A global issue. JAMA 1997;278:1377. Crome P, Flanagan RJ: Pharmacokinetic studies in elderly people – are they necessary? Clin Pharmacokinet 1994;26:243–247. Herrlinger C, Klotz U: Drug metabolism and drug interactions in the elderly. Best Pract Res Clin Gastroenterol 2001;15:897–918. Turnheim K: Drug dosage in the elderly. Is it rational? Drugs Aging 1998;13:357–379. Wilkinson GR: The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans.

This meta-analysis included published data from the 28 controlled trials completed at that date, involving nearly 10,000 patients, and was also able to include substantial amounts of unpublished data systematically retrieved from many of the studies. The meta-analysis identified five GAP types: hospital units (six studies), hospital consultation teams (eight studies), in-home assessment services (seven studies), outpatient assessment services (four studies) and ‘hospital-home assessment services’ (three studies), the latter of which performed in-home assessments on patients recently discharged from hospitals.

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Aging and the Gastrointestinal Tract by A. Pilotto, P. Malfertheiner, P.R. Holt, T. Fulop

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