By John D. Pickard, Nejat Akalan, Vladimir Benes, Concezio Di Rocco, Vinko V. Dolenc, J. Lobo Antunes, Johannes Schramm, Marc Sindou
The ambition of all winning editorial forums has been to supply a chance for mature scholarship and mirrored image, now not limited by way of man made limits on area. The sequence presents a outstanding acocunt of development over the last 35 years, either with reference to advances, distinct descriptions of normal operative strategies and in-depth experiences of tested wisdom. the current quantity is a brand new enterprise and identification involved in a unmarried subject specifically - low-grade gliomas. It encompasses a multidisciplinary procedure that are meant to attract either skilled neurosurgeons and younger neurosurgeons in education alike.
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Additional info for Advances and Technical Standards in Neurosurgery, Vol. 35: Low-Grade Gliomas
51 51 51 51 51 52 53 53 56 57 Abstract The term ‘‘low-grade glioma’’ refers to a heterogeneous group of slowly growing glial tumors corresponding histologically to World Health Organization (WHO) grade I or II. This group includes astrocytic, oligodendroglial, oligoastrocytic and ependymal tumor entities, most of which preferentially manifest in children and young adults. Depending on histological type and WHO grade, growth patterns of low-grade gliomas are quite variable, with some tumors diffusely inﬁltrating the surrounding central nervous system tissue and others showing well demarcated growth.
Recurrent tumours have increased metabolic activity whereas areas of radiation necrosis are hypometabolic . FDG can differentiate between these two with a sensitivity of 75% and speciﬁcity of 81% . MR coregistration improves the sensitivity of FDG as it can distinguish recurrence uptake in the normal adjacent cortex. It can be misleading, however, as increased activity can be due to accumulation of activated macrophages. The real limitation using FDG to assess brain tumours is that the uptake is non-speciﬁc and can occur in any region with an increase in metabolic activity.
Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Pleomorphic xantoastrocytoma (WHO grade II) . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Pilocytic astrocytoma (WHO grade I) . . . . . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . .
Advances and Technical Standards in Neurosurgery, Vol. 35: Low-Grade Gliomas by John D. Pickard, Nejat Akalan, Vladimir Benes, Concezio Di Rocco, Vinko V. Dolenc, J. Lobo Antunes, Johannes Schramm, Marc Sindou