By E. D. Thomas (auth.), Prof. Dr. T. Büchner, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter (eds.)
The charges of acute leukemia treatment have steadily better during the last decade. medical examine effects mirror the influence of chemotherapy depth and period, the position of lengthy upkeep, intensified consolidation or very early intensification. extra development has additionally been accomplished in bone marrow trans plantation, and up to date potential reports and meta-analyses have contributed comparisons of the excessive antileukemic efficacy of bone marrow transplantation to that of more desirable chemotherapy. this permits a extra profitable combining of the 2 types of therapy. New prognostic components have emerged from either cytogenetic and molecular genetic learn. therefore, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have confirmed to be the dominating chance think about acute lymphoblastic leukemia. because the frequency raises with age, modifications in analysis among teenagers and adults will be defined. evaluate of molecular and immunologic leukemia mobilephone markers has supplied a greater realizing of residual leukemia in scientific remission, as a prognostic issue and in tracking the effectiveness of the antileukemic procedure. contemporary paintings on leukemic telephone biology has led to novel healing techniques comparable to terminal differentiation through all-trans-retinoic acid, modulation of chemotherapy by way of hematopoietic progress components resembling GM-CSF and enhancement of immunologic keep an eye on by means of cytokines resembling interleukin 2. New antimicrobial medicines and the appliance of usually empiric anti-infectious ideas have helped lowering the healing threat. hence, a few contemporary achievements have supplied us with new thoughts within the administration of sufferers with acute leukemias.
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Additional resources for Acute Leukemias IV: Prognostic Factors and Treatment Strategies
For patients with a donor, these data indicate that marrow grafting is the route of choice for early relapsing patients while chemotherapy is the choice for late relapsing patients with the marrow graft held in reserve in the event of a further relapse. Current Research Recurrence of leukemia after chemotherapy or after marrow grafting continues to be a major problem. After either form of treatment, recur- 3 rence carries a high probability of death from leukemia. For chemotherapy, only minimal improvement in remission duration and diseasefree survival has been achieved in the past two decades despite intensive research involving various combinations of old and new agents.
Hansen, D. Nielsen, T. C. Sigsgaard, L. Specht, and K. ctlsterlind Introduction Risk Estimates of t-MDS and t-AML in Seven Danish Cohort Studies For more than 20 years the many aspects of t-MDS and t-AML, including risk factors incidence and chromosome characteristics' have been evaluated in numerous studies, a~ reviewed extensively elsewhere [1-7]. The risk has primarily been related to previous therapy with the alkylating agents, but more recently also to therapy with the epipodophyllotoxins.
Blood 74: 334--342 Foroni L, Laffen M, Boeham T, Rabbits TH, Catovsky D, Luzzato L (1989) Rearrangement of the T-cell receptor I) genes in human T-cell leukemias. Blood 3: 559-566 Loiseau P, Guglielmi P, LePaslier D, MacIntyre E, Gessain A, Bories lC, Flandrin G, Chen Z, Sigaux F (1989) Rearrangements of the T-cell receptor I) gene in T-acute lymphoblastic leukemia cells are distinct from those occurring in B-lineage acute lymphoblastic leukemia and preferentially involve one VI) gene segment. 1 Immunol 142: 3305-311 Griesinger F, Greenberg 1M, Kersey lH (1989) T cell receptor gamma and delta rearrangements in hematologic malignancies.
Acute Leukemias IV: Prognostic Factors and Treatment Strategies by E. D. Thomas (auth.), Prof. Dr. T. Büchner, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter (eds.)